Heart Failure Quick Guide
Find medication information including dosages and medications to avoid, preventive care guidelines for your heart failure patients, information about ischemic evaluation and heart failure with preserved ejection fraction (HFpEF).
Not sure when to refer to specialty care? We have a quick guide for that.
Ready to take the next steps to excellence in managing heart failure in primary care? Review the Mount Sinai Heart Failure Care Pathway or discover services available to MSHP Clinically Integrated Network providers to achieve team-based care.
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Medications
Starting and Target Doses of Select Guideline-Directed Medical Therapy (GDMT) for HF
Starting Dose | Target Dose | |
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ARNI |
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Sacubitril/valsartan | 24/26 mg - 49/51 mg 2x daily | 97/103 mg 2x daily |
ACEI |
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Captopril | 6.25 mg 3x daily | 50 mg 3x daily |
Enalapril | 2.5 mg 2x daily | 10-20 mg 2x daily |
Lisinopril | 2.5-5 mg daily | 20-40 mg daily |
Ramipril | 1.25 mg daily | 10 mg daily |
ARB |
||
Candesartan | 4-8mg daily | 32mg daily |
Losartan | 25-50 mg daily | 150 mg daily |
Valsartan | 40 mg 2x daily | 160mg 2x daily |
Beta Blockers |
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Bisoprolol | 1.25 mg daily | 10 mg daily |
Carvedilol | 3.125 mg 2x daily | 25 mg 2x daily for weight <85kg; 50 mg daily for weight =85 kg |
Metoprolol succinate* | 12.5 - 25 mg daily | 200 mg daily |
Aldosterone Antagonists |
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Eplerenone | 25 mg daily | 50 mg daily |
Spironolactone | 12.5 - 25 mg daily | 25-50 mg daily |
SGLT2 Inhibitors |
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Dapagliflozin | 10 mg daily | 10 mg daily |
Empagliflozin | 10 mg daily | 10 mg daily |
Vasodilators |
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Hydralazine | 25 mg 3x daily | 75 mg 3x daily |
Isosorbide dinitrate | 20 mg 3x daily | 40 mg 3x daily |
Fixed-dose combination isosorbide dinitrate/hydralazine | 20 mg/37.5 mg (one tab) 3x daily | 2 tabs 3x daily |
Ivabradine |
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Ivabradine | 2.5-5 mg 2x daily | 10 mg daily |
Diuretics — Loop |
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Bumetanide | 0.5 - 1 mg 1x or 2x daily | 10 mg daily |
Furosemide | 20-40 mg 1x or 2x daily | 400 mg daily |
Torsemide | 10-20 mg daily | 200 mg daily |
Digoxin |
||
Digoxin | 0.125 mg daily | 0.25 mg daily |
*Unlike immediate-releases metoprolol, metoprolol ER is proven to improve symptoms of heart failure, lower the risk of death from heart failure, and lower the risk of hospitalization due to heart problems. While atenolol is technically another hypertension drug, it doesn't have these additional benefits. |
Medications to Avoid in Heart Failure Patients
NSAIDs in all types of HF |
Third generation calcium channel blockers such as amlodipine may be used for blood pressure control in HFrEF. Other calcium channel blockers such as verapamil, diltiazem, and nifedipine should be avoided in patients with HFrEF. |
Routine use of nitrates in HFpEF |
Medication questions? Contact the MSHP Pharmacy Team.
Preventive Care
Vaccinations for Heart Failure Patients
Influenza vaccine |
Recommended for all patients with HF |
Pneumococcal vaccine |
The PPSV23 is recommended for all adult patients with heart failure. Administration of PCV13 should also be considered for patients = 65 years old |
When to Refer to a Specialist
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New-onset HF (regardless of EF): Refer for evaluation of etiology, guideline-directed evaluation and management of recommended therapies, and assistance in disease management, including consideration of advanced imaging, endomyocardial biopsy, or genetic testing for primary evaluation of new-onset HF
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Chronic HF with high-risk features, such as development of 1 more of the following risk factors:
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Need for chronic IV inotropes
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Persistent NYHA functional class III-IV symptoms
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Systolic blood pressure =90 mm Hg or symptomatic hypotension
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Creatinine =1.8 mg/dl or BUN =43 mg/dl
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Onset of atrial fibrillation, ventricular arrthymias, or repetitive ICD shocks
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Two or more ED visits or hospitalizations for worsening HF in prior 12 months
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Inability to tolerate optimally dosed beta-blockers and/or ACI/ARB/ARNU and/or aldosterone antagonists
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Clinical deterioration, as indicated by worsening edema, rising biomarkers (BNP, NT-proBNP, others), worsened exercise testing, decompensated hemodynamics, or evidence of progressive re-modeling on imaging
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High mortality risk using a validated risk model for further assessment and consideration of advanced therapies, such as Seattle Heart Failure Model
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To assist with management of GDMT, including replacement of ACEI or ARB therapy with ARNI for eligible patients or to address comorbid conditions such as chronic renal disease or hyperkalemia, which may complicate treatment.
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Persistent reduced LVEF at or below 35% despite GDMT for at least 3 months for consideration of device therapy in those patients without prior placement of ICD or CRT, unless device therapy contraindicated or inconsistent with overall goals of care
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Annual review of patients with established advanced HF in which patients/caregivers and clinicians discuss current and potential therapies for both anticipated and unanticipated events, possible HF disease trajectory and prognosis, patient preferences, and advanced care planning.
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Assessment of patient for possible participation in a clinical trial
Find a cardiologist
Heart Failure with Preserved Ejection Fraction (HFpEF)
HFpEF treatment focuses on maintaining euvolemia and effectively managing associated comorbidities (coronary artery disease, hypertension, atrial fibrilation, diabetes mellitus, obstructive sleep apnea)
Next Steps
Read the Mount Sinai Heart Failure Pathway for in-depth, evidence-based guidelines for managing your heart failure outpatients
Explore Team-Based Care services available to you and your practice as a member of MSHP's Clinically Integrated Network
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